https://ogma.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:31519 F508del) or NBS-positive but discharged following sweat chloride < 60 mmol/L. Cases of LD-CF were each matched 1:2 with patients with NBS-CF for age, sex, hospital, and exocrine pancreatic status. Results: A total of 45 LD-CF cases were identified (39 NBS-negative and 6 NBS-positive) with 90 NBS-CF matched controls. Median age (IQR) of diagnosis for LD-CF and NBS-CF was 1.35 (0.4-2.8) and 0.12 (0.03-0.2) years, respectively (P <.0001). Estimated incidence of LD-CF was 1 in 45 000 live births. Compared with NBS-CF, LD-CF had more respiratory manifestations at time of diagnosis (66% vs 4%; P <.0001), a higher rate of hospital admission per year for respiratory illness (0.49 vs 0.2; P = .0004), worse lung function (forced expiratory volume in 1 second percentage of predicted, 0.88 vs 0.97; P = .007), and higher rates of chronic colonization with Pseudomonas aeruginosa (47% vs 24%; P = .01). The LD-CF cohort also appeared to be shorter than NBS-CF controls (mean height z-score −0.65 vs −0.03; P = .02). Conclusions: LD-CF, despite NBS, seems to be associated with worse health before diagnosis and worse later growth and respiratory outcomes, thus providing further support for NBS programs for CF.]]> Wed 24 Nov 2021 15:52:38 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41976 Wed 08 Nov 2023 09:55:46 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51276 Tue 29 Aug 2023 15:47:54 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46265 1.5 mm and <72 hours after birth were randomized to NSAIDs vs placebo. No open-label NSAID treatment was allowed in either arm, but all infants with PDA volume load received supportive management, including optimization of airway pressure, careful fluid management, and diuretics as needed. The pilot outcomes were recruitment rate and incidence of open-label treatment. Secondary clinical outcomes included chronic lung disease or death, the planned primary outcome for a future large trial. Results: Overall, 54% of the approached parents consented to participate in the study. The median recruitment rate was 3 infants per month, and a total of 72 infants were randomized. One patient in each arm received open-label treatment. PDA closure rates were 74% for the NSAIDs arm vs 30% for the placebo arm, but this was not associated with significant changes in clinical outcomes. Conclusions: This pilot trial showed that recruitment of more than one-half of eligible infants with a low incidence of open-label treatment is feasible. PDA closure rates and clinical outcomes were similar to those reported in previous PDA trials.]]> Tue 15 Nov 2022 08:57:56 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41245 Sat 30 Jul 2022 12:33:27 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:9451 Sat 24 Mar 2018 10:44:31 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:3025 Sat 24 Mar 2018 08:30:02 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:10796 50% compared with the initial measurement is associated with mortality.]]> Sat 24 Mar 2018 08:08:18 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20907 6500 counts/min). Secondary outcomes included sedentary behavior, cardiorespiratory fitness, overweight status, and blood pressure. Results: Among the 306 youth studied, those who reported spending most/all of their after-school time outdoors (n = 120) participated in more MVPA (61.0 ± 24.3 vs 39.9 ± 19.1 min/day; adjusted P < .001), were more likely to achieve the recommended minimum 60 min/day of MVPA (aOR 2.8; 95% CI, 1.3-6.4), spent less time in sedentary activities (539 ± 97 min/day vs 610 ± 146 min/day; adjusted P < .001), and had higher cardiorespiratory fitness (49 ± 5 vs 45 ± 6 mL/kg/min; adjusted P < .001) than youth who reported no time outdoors (n = 52). No differences in overweight/obesity or blood pressure were observed across the groups. Conclusions: Time spent outdoors is positively associated with MVPA and cardiorespiratory fitness in youth and negatively associated with sedentary behavior. Experimental trials are needed to determine whether strategies designed to increase time spent outdoors exert a positive influence on physical activity and fitness levels in youth.]]> Sat 24 Mar 2018 07:57:55 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:27523 Sat 24 Mar 2018 07:28:54 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:23311 Sat 24 Mar 2018 07:13:31 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51236 Mon 28 Aug 2023 12:19:24 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:40735 Mon 18 Jul 2022 12:51:18 AEST ]]>